Prospects of the Application of Some Species of the Lamiaceae Family and Some Features of the Development of Their Tinctures: Prospects of the Appicationof Some Species of the Lamiaceae Family

Abstract

The search for new powerful herbal products with anti-inflammatory, antimicrobial and antinociceptive activities presents an important area of pharmaceutical research. Some plants of the Lamiaceae family are well‑known for their significant antimicrobial, anti-inflammatory, and pain‑relieving activities. Species of the Lamiaceae attract a great scientific interest mainly due to the diversity of terpenes and phenolic compounds, including phenolic acids and flavonoids. Essential oils possess certain antimicrobial activity. For experimental studies, we selected four herbs. Among them were Monarda fistulosa L., Satureja hortensis L., Thymus vulgaris L., and Mentha piperita L. Four tinctures of the above-mentioned herbs were elaborated and partly phytochemically evaluated. We established the coefficients of alcohol absorption for the tested raw materials and the maximum absorption for active markers and tinctures after adding aluminum chloride that is needed for the development and standardization of tinctures. The solutions of complexes aluminum chloride with quercetin (20 mg/L), rutin (50.2 mg/L), and chrysin (80 mg/L) had the maximum absorption at the wavelengths of 425.9 ±0.3 nm at 77 min of the reaction, 412.3 ±0.3 nm at 82 min, 388.4 ±0.7 nm at 81 min, respectively. The tinctures of Monarda fistulosa, Satureja hortensis, Thymus vulgaris, and Mentha piperita had the maximum absorption at 391.2 ±0.5 nm at 91 min, 389.9 ±0.5 nm at 76 min, 391.8 nm at 83 min, 394.9 ±1.1 nm at 78 min, respectively. The carried out spectrophotometric studies confirmed the prevalence of flavones in the tested tinctures, considering the proximity of the maximum absorption of the tested tinctures and chrysin. The next studies will be continued at the standardization of the developed tinctures and the establishment of their antimicrobial activity.